Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 1.00 |
| ▸ | FLT3 | P36888 | 4/20 | 0.66 |
| ▸ | MET | P08581 | 14/20 | 0.65 |
| ▸ | EGFR | P00533 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | MST1R | Q04912 | 4/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.65 |
| ▸ | FLT4 | P35916 | 3/20 | 0.65 |
| ▸ | TEK | Q02763 | 3/20 | 0.65 |
| ▸ | BTK | Q06187 | 3/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | STK25 | O00506 | 1/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30000966 | 1.00 | AXL (1.00) | AXLFLT3METEGFRKDR | |
| SCHEMBL166239 | 1.00 | AXL (1.00) | AXLFLT3METEGFRKDR | |
| SCHEMBL1591152 | 0.96 | AXL (0.92) | AXLFLT3METEGFRKDR | |
| SCHEMBL29908856 | 0.96 | AXL (0.92) | AXLFLT3METEGFRKDR | |
| SCHEMBL14289192 | 0.96 | AXL (0.92) | AXLFLT3METEGFRKDR | |
| SCHEMBL15262000 | 0.92 | AXL (0.85) | AXLFLT3METKDRMST1R | |
| SCHEMBL698905 | 0.91 | AXL (0.84) | AXLFLT3METEGFRKDR | |
| SCHEMBL1554813 | 0.91 | AXL (0.84) | AXLMET | |
| SCHEMBL13896124 | 0.90 | AXL (0.82) | AXLFLT3METEGFRKDR | |
| SCHEMBL30465532 | 0.90 | AXL (0.81) | AXLFLT3METEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | METHYLGENE, INC. (CA) | 2008-01-03 | — | — | US | disclosed |
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | METHYLGENE, INC. (CA) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004273-A1 | Inhibitors of protein tyrosine kinase activity | HGF, ERBB2, MET | AXL 130/4885FLT3 10/4885MET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.