SCHEMBL2990894

SCHEMBL2990894

C=C1C=CCc2c1ccc1ccccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.40
CYP1A2 P05177 3/20 0.40
HPGD P15428 3/20 0.40
CYP2C19 P33261 3/20 0.40
KDM4E B2RXH2 3/20 0.40
CYP2C9 P11712 2/20 0.40
GLA P06280 1/20 0.40
SIRT1 Q96EB6 1/20 0.40
ALDH1A1 P00352 5/20 0.38
TDP1 Q9NUW8 2/20 0.38
CYP2A6 P11509 1/20 0.38
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
HTT P42858 1/20 0.36
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36
NCOA1 Q15788 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
HPRT1 P00492 1/20 0.35
HIF1A Q16665 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6249376 0.79 CYP1A2 (0.49) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL1395078 0.79 ALDH1A1 (0.38) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL10446466 0.75 TDP1 (0.35) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL2290546 0.73 HSD17B10 (0.44) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL29399101 0.73 HSD17B10 (0.44) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL31450268 0.72 HSD17B10 (0.42) HSD17B10CYP1A2HPGDCYP2C19KDM4E
Benzene SCHEMBL1724439 0.72 HSD17B10 (0.42) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL7526281 0.71 ALDH1A1 (0.38) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL16009053 0.68 ALDH1A1 (0.42) HSD17B10CYP1A2HPGDCYP2C19KDM4E
SCHEMBL28107722 0.68 HPRT1 (0.45) HSD17B10CYP1A2HPGDCYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0253529-B1 FLUORINATED POLYCYCLIC COMPOUNDS ISC CHEMICALS LIMITED (GB) 1990-09-26 EP claimed
EP-0253529-A1 Fluorinated polycyclic compounds ISC CHEMICALS LIMITED (GB) 1988-01-20 EP claimed
EP-2009304-B1 TORQUE LIMITER JTEKT CORP (JP) 2014-10-01 EP disclosed
EP-2003353-B1 TORQUE LIMITER JTEKT CORP (JP) 2014-06-04 EP disclosed
US-8230986-B2 Torque limiter JTEKT CORPORATION (JP) 2012-07-31 US disclosed
US-8220609-B2 Torque limiter JTEKT CORPORATION (JP) 2012-07-17 US disclosed
US-20100184519-A1 TORQUE LIMITER JTEKT CORPORATION (JP) 2010-07-22 US disclosed
US-20090173591-A1 TORQUE LIMITER JTEKT CORPORATION (JP) 2009-07-09 US disclosed
EP-2009304-A1 TORQUE LIMITER JTEKT Corporation (JP) 2008-12-31 EP disclosed
EP-2003353-A1 TORQUE LIMITER JTEKT Corporation (JP) 2008-12-17 EP disclosed
EP-1200491-A1 ETHYLENE AND/OR ALPHA-OLEFIN/VINYL OR VINYLIDENE AROMATIC INTERPOLYMER COMPOSITIONS THE DOW CHEMICAL COMPANY (US) 2002-05-02 EP disclosed
US-4895990-A HIGH TEMPERATURE VAPOR SOLDERING FLUID, HEAT TRANSFER I.S.C. CHEMICALS LIMITED (GB) 1990-01-23 US disclosed
EP-0253529-A1 Fluorinated polycyclic compounds ISC CHEMICALS LIMITED (GB) 1988-01-20 EP disclosed
EP-0082967-B1 TRACTION FLUID Optimol-Ölwerke GmbH (DE) 1987-09-23 EP disclosed
US-4499000-A Power-transmission method uses spirocyclic ketals BAYER AKTIENGESELLSCHAFT (DE) 1985-02-12 US disclosed
EP-0047448-B1 HYDRAULIC FLUID BAYER AG (DE) 1983-09-21 EP disclosed
EP-0082967-A2 Traction fluid Optimol-Ölwerke GmbH (DE) 1983-07-06 EP disclosed
EP-0047448-A2 Hydraulic fluid BAYER AG (DE) 1982-03-17 EP disclosed
US-4075157-A PRODUCTION OF NON-CARCINOGENIC CARBON BLACK PHILLIPS PETROLEUM COMPANY (US) 1978-02-21 US disclosed
US-4075160-A NON-CARCINOGENIC CARBON BLACK PHILLIPS PETROLEUM COMPANY (US) 1978-02-21 US disclosed