SCHEMBL29909025

SCHEMBL29909025

CN(c1cccc(-c2ccc(C(C)(C)C)nc2)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.37
FNTB P49356 1/20 0.37
CCR9 P51686 1/20 0.34
CSNK2A2 P19784 1/20 0.31
CSNK2B P67870 1/20 0.31
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
MAT2A P31153 6/20 0.31
ABCG2 Q9UNQ0 1/20 0.31
PDE4B Q07343 1/20 0.30
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30
PRMT5 O14744 3/20 0.30
CYP1A2 P05177 1/20 0.30
GRM4 Q14833 1/20 0.30
CYP3A4 P08684 1/20 0.30
CSF1R P07333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577131 1.00 FNTA (0.37) FNTAFNTBCCR9CSNK2A2CSNK2B
SCHEMBL23601379 0.93 FNTA (0.36) FNTAFNTBCSNK2A2CSNK2BTP53
SCHEMBL29909845 0.93 FNTA (0.36) FNTAFNTBCSNK2A2CSNK2BTP53
SCHEMBL23577097 0.93 FNTA (0.36) FNTAFNTBCSNK2A2CSNK2BTP53
SCHEMBL23601434 0.92 FNTA (0.36) FNTAFNTBABCG2
SCHEMBL31169421 0.92 FNTA (0.36) FNTAFNTBABCG2
SCHEMBL23601633 0.89 FNTA (0.40) FNTAFNTBCSNK2A2CSNK2BTP53
SCHEMBL29909493 0.89 FNTA (0.36) FNTAFNTBCCR9CSNK2A2CSNK2B
SCHEMBL23576662 0.89 FNTA (0.36) FNTAFNTBCCR9CSNK2A2CSNK2B
SCHEMBL23576895 0.88 FNTA (0.37) FNTAFNTBCSNK2A2CSNK2BTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed