Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577034 | 1.00 | MAPT (0.44) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29909785 | 0.87 | KDM4E (0.44) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23577285 | 0.87 | KDM4E (0.44) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23601086 | 0.84 | KDM4E (0.61) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27235793 | 0.83 | MAPT (0.41) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23576644 | 0.83 | NPC1 (0.41) | MAPTNPC1ALDH1A1GAACACNA2D1 | |
| SCHEMBL29909620 | 0.83 | NPC1 (0.41) | MAPTNPC1ALDH1A1GAACACNA2D1 | |
| SCHEMBL29991937 | 0.75 | ATM (0.47) | MAPTKDM4ENPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL38656278 | 0.74 | KMT2A (0.41) | MAPTNPC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL21072505 | 0.73 | PARP14 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |