SCHEMBL29909222

SCHEMBL29909222

CN(c1cccc(F)c1)c1ncnc2cc(F)c(F)cc12

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 14/20 0.58
EGFR P00533 14/20 0.58
RET P07949 1/20 0.52
KIF5B P33176 1/20 0.52
KDR P35968 1/20 0.52
PDGFRB P09619 1/20 0.50
PDGFRA P16234 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577016 0.78 ABCG2 (0.53) CSF1REGFRKDRPDGFRBABCG2
SCHEMBL29909796 0.78 ABCG2 (0.53) CSF1REGFRKDRPDGFRBABCG2
SCHEMBL30013727 0.77 EGFR (0.52) CSF1REGFRRETKIF5BKDR
SCHEMBL23576665 0.76 ABCG2 (0.50) ABCG2
SCHEMBL29909290 0.76 ABCG2 (0.50) ABCG2
SCHEMBL7473885 0.74 EGFR (0.46) CSF1REGFRRETKIF5BKDR
Hydrochloric Acid SCHEMBL6179698 0.72 CSF1R (1.00) CSF1REGFRRETKIF5BKDR
SCHEMBL27876061 0.72 CSF1R (0.49) CSF1REGFRRETKIF5BKDR
SCHEMBL4353191 0.70 EGFR (0.64) CSF1REGFRPDGFRBPDGFRA
SCHEMBL28004917 0.70 CSF1R (0.71) CSF1REGFRRETKDRPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed