SCHEMBL29909418

SCHEMBL29909418

C=Cc1ccc2c(N(C)c3cccc(-c4ccc(Cl)cc4)c3)nc3nncn3c2c1

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.35
FNTB P49356 1/20 0.35
TP53 P04637 2/20 0.33
MAPT P10636 2/20 0.33
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
ABCG2 Q9UNQ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577570 1.00 FNTA (0.35) FNTAFNTBTP53MAPTPOLB
SCHEMBL23576867 0.92 MAPT (0.32) MAPTPOLBABCG2
SCHEMBL29909268 0.92 MAPT (0.32) MAPTPOLBABCG2
SCHEMBL29909377 0.91 FNTA (0.35) FNTAFNTBTP53MAPTPOLB
SCHEMBL23576641 0.91 FNTA (0.35) FNTAFNTBTP53MAPTPOLB
SCHEMBL23601235 0.89 FNTA (0.40) FNTAFNTBTP53MAPTPOLB
SCHEMBL29909768 0.89 FNTA (0.40) FNTAFNTBTP53MAPTPOLB
SCHEMBL23578008 0.89 TP53 (0.36) TP53MAPTSMN1; SMN2
SCHEMBL23576883 0.89 ASIC1 (0.33) FNTAFNTB
SCHEMBL29909412 0.89 ASIC1 (0.33) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed