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ASIC1

Acid-sensing ion channel 1 · P78348 · ASIC1 on Sugi Atlas →

601 patent compounds predicted against ASIC1, 352 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL5000129) 0.40 4/20
SCHEMBL20184769 SCHEMBL20184769 0.55 3/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL4714469) 0.34 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL5703072) 0.81 2/20
SCHEMBL29936120 SCHEMBL29936120 0.54 2/20
SCHEMBL29936503 SCHEMBL29936503 0.54 2/20
SCHEMBL7995817 SCHEMBL7995817 0.53 2/20
SCHEMBL2252981 SCHEMBL2252981 0.52 2/20
SCHEMBL2257761 SCHEMBL2257761 0.52 2/20
SCHEMBL17372934 SCHEMBL17372934 0.51 2/20
SCHEMBL14973090 SCHEMBL14973090 0.50 2/20
SCHEMBL2667860 SCHEMBL2667860 0.49 2/20
SCHEMBL4682039 SCHEMBL4682039 0.47 2/20
SCHEMBL4683641 SCHEMBL4683641 0.46 2/20
SCHEMBL14445949 SCHEMBL14445949 0.46 2/20
SCHEMBL8369096 SCHEMBL8369096 0.46 2/20
SCHEMBL13003051 SCHEMBL13003051 0.46 2/20
SCHEMBL9254707 SCHEMBL9254707 0.45 2/20
SCHEMBL4681912 SCHEMBL4681912 0.45 2/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL4791161) 0.45 2/20

Clinical trials — most relevant to ASIC1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers PHASE4COMPLETED
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma PHASE4COMPLETED
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1 PHASE3ACTIVE_NOT_RECRUITING
Suzetrigine in Total Hip Arthroplasty PHASE3RECRUITING
Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve PHASE2UNKNOWN
Influence on Cough and Airway Symptoms by Oral Capsaicin PHASE2ACTIVE_NOT_RECRUITING
Efficacy of OnabotulinumtoxinA in Migraine PHASE2COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive Heartburn PHASE1COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival PHASE1UNKNOWN
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
The Role of NaV1.8 in Human Pain Models EARLY_PHASE1COMPLETED
Precision Medicine for Sng/Pain Control nanCOMPLETED
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Precision Medicine for Nociception, Sngception and Proprioception. nanRECRUITING
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Microcirculation & ASICs nanCOMPLETED
The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in Health nanCOMPLETED
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis nanUNKNOWN
The Effect of Acute Tryptophan Depletion (ATD) on Esophageal Sensitivity in Healthy Volunteers nanCOMPLETED
Detection of Clinically Significant Prostate Cancer Using a Urinary Multimarker Sensor nanUNKNOWN
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene nanRECRUITING
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Sodium Channel Splicing in Heart Failure Trial nanCOMPLETED
Pulsed Radiofrequency in Chronic Lumbosacral Radicular Pain nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ASIC1 binder may also engage these)

ProteinNameSimilarity
Q6NXK8 — 1.000 Q6NXK8 →
P55926 — 0.995 P55926 →
Q1XA76 — 0.993 Q1XA76 →
Q7T1N4 — 0.989 Q7T1N4 →
Q925H0 — 0.988 Q925H0 →
Q62962 — 0.987 Q62962 →
Q708S6 — 0.986 Q708S6 →
Q708S5 — 0.985 Q708S5 →
Q708S7 — 0.983 Q708S7 →
Q16515 — 0.982 Q16515 →
Q708S4 — 0.979 Q708S4 →
Q708S3 — 0.977 Q708S3 →
Q92075 — 0.970 Q92075 →
K7GET2 — 0.966 K7GET2 →
Q95165 — 0.963 Q95165 →
O97742 — 0.959 O97742 →
Q708S8 — 0.959 Q708S8 →
SCNN1B Epithelial sodium channel subunit beta 0.959 landscape →
A5D7U4 — 0.959 A5D7U4 →
P37090 — 0.956 P37090 →
Q9WU38 — 0.956 Q9WU38 →
H9GBX2 — 0.956 H9GBX2 →
P02713 — 0.952 P02713 →
P51167 — 0.952 P51167 →
O62816 — 0.952 O62816 →
K7FQW8 — 0.951 K7FQW8 →
P04759 — 0.949 P04759 →
Q68RJ7 — 0.948 Q68RJ7 →
ASIC3 Acid-sensing ion channel 3 0.948 landscape →
P02717 — 0.947 P02717 →