SCHEMBL29909549

SCHEMBL29909549

CN(c1cccc(-c2ccc(C(C)(F)F)cc2)n1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FNTA P49354 3/20 0.39
FNTB P49356 3/20 0.39
TP53 P04637 2/20 0.35
MAPT P10636 2/20 0.35
POLB P06746 1/20 0.32
MAT2A P31153 4/20 0.31
PRMT5 O14744 2/20 0.31
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23576773 1.00 FNTA (0.39) FNTAFNTBTP53MAPTPOLB
SCHEMBL23600528 0.93 FNTA (0.38) FNTAFNTBTP53MAPTPOLB
SCHEMBL29909757 0.93 FNTA (0.38) FNTAFNTBTP53MAPTPOLB
SCHEMBL23576704 0.91 TP53 (0.38) FNTAFNTBTP53MAPTPOLB
SCHEMBL23578130 0.88 FNTA (0.34) FNTAFNTBMAT2APRMT5CYP1A2
SCHEMBL31229690 0.85 FNTA (0.41) FNTAFNTBTP53MAPTPOLB
SCHEMBL23577102 0.85 FNTA (0.41) FNTAFNTBTP53MAPTPOLB
SCHEMBL23577807 0.85 PTGS2 (0.37) FNTAFNTBTP53MAPTMAT2A
SCHEMBL23601277 0.81 MAT2A (0.36) FNTAFNTBMAT2APRMT5CYP1A2
SCHEMBL23601905 0.78 FNTA (0.40) FNTAFNTBTP53MAPTMAT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed