Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874090 | 1.00 | RIPK1 (0.65) | RIPK1HSD11B1EP300NCOA1NCOA3 | |
| SCHEMBL17874096 | 0.95 | RIPK1 (0.61) | RIPK1HSD11B1EP300NCOA1NCOA3 | |
| SCHEMBL29912620 | 0.95 | RIPK1 (0.61) | RIPK1HSD11B1EP300NCOA1NCOA3 | |
| SCHEMBL17882197 | 0.79 | RIPK1 (1.00) | RIPK1HSD11B1MEN1KMT2AHDAC4 | |
| SCHEMBL17882182 | 0.77 | RIPK1 (0.87) | RIPK1HSD11B1MEN1KMT2A | |
| SCHEMBL17882203 | 0.77 | RIPK1 (1.00) | RIPK1HSD11B1MEN1KMT2AHDAC4 | |
| SCHEMBL17882290 | 0.75 | RIPK1 (1.00) | RIPK1MEN1KMT2A | |
| SCHEMBL17882289 | 0.71 | RIPK1 (0.65) | RIPK1HSD11B1CYP3A4MEN1KMT2A | |
| SCHEMBL3518014 | 0.69 | AKR1C1 (0.61) | HSD11B1EP300NCOA1NCOA3AKR1C1 | |
| SCHEMBL3326634 | 0.69 | HSD11B1 (0.78) | RIPK1HSD11B1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197098-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2023-08-08 | — | — | CN | disclosed |
| CN-115197098-A | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-10-18 | — | — | CN | disclosed |
| CN-107108467-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2022-08-19 | — | — | CN | disclosed |