Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157819 | 1.00 | RBP4 (0.47) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL29912864 | 0.90 | GPR119 (0.47) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL27158392 | 0.90 | GPR119 (0.47) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL30785526 | 0.89 | RBP4 (0.51) | RBP4SSTR4TTR | |
| SCHEMBL30785481 | 0.84 | RBP4 (0.53) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL27157998 | 0.84 | RBP4 (0.53) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL29202348 | 0.84 | RBP4 (0.53) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL30785499 | 0.84 | RBP4 (0.53) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL30785509 | 0.83 | RBP4 (0.54) | RBP4GPR119SSTR4ALOX5APFEN1 | |
| SCHEMBL27158623 | 0.83 | RBP4 (0.54) | RBP4GPR119SSTR4ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329881-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232383-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2022-11-03 | — | — | WO | disclosed |