Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 15/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.42 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914153 | 0.84 | USP1 (0.61) | USP1STIM1ORAI1WDR48 | |
| SCHEMBL30017039 | 0.79 | USP1 (0.63) | USP1STIM1ORAI1WDR48 | |
| SCHEMBL22122048 | 0.78 | USP1 (0.80) | USP1WDR48 | |
| SCHEMBL30707810 | 0.78 | USP1 (0.80) | USP1WDR48 | |
| SCHEMBL6946826 | 0.77 | HDAC6 (0.62) | HDAC1HDAC6USP2CYP1A2CYP3A4 | |
| SCHEMBL30816531 | 0.77 | USP1 (0.59) | USP1STIM1ORAI1WDR48USP2 | |
| SCHEMBL6944736 | 0.75 | HDAC1 (0.62) | HDAC1HDAC6USP2CYP1A2CYP3A4 | |
| SCHEMBL22122054 | 0.74 | USP1 (1.00) | USP1WDR48 | |
| SCHEMBL22122063 | 0.73 | USP1 (0.48) | USP1STIM1ORAI1CYP1A2CYP3A4 | |
| SCHEMBL25202898 | 0.72 | USP1 (0.56) | USP1STIM1ORAI1WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022228399-A1 | TRICYCLIC USP1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-11-03 | — | — | WO | disclosed |