Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914348 | 0.88 | KMT2A (0.39) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL29914351 | 0.87 | KMT2A (0.39) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL29914352 | 0.80 | CYP3A4 (0.40) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL4464611 | 0.71 | SMN1; SMN2 (0.47) | KMT2ACYP3A4CYP2C9SMN1; SMN2CYP1A2 | |
| SCHEMBL22504981 | 0.68 | KMT2A (0.59) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL23365250 | 0.65 | CYP3A4 (0.43) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL24590357 | 0.64 | MEN1 (0.55) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL23378500 | 0.64 | CYP3A4 (0.57) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL24590147 | 0.63 | KMT2A (0.54) | KMT2AMEN1RXFP1CYP3A4CYP2C9 | |
| SCHEMBL24590317 | 0.62 | MEN1 (0.53) | KMT2AMEN1RXFP1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279754-A | Isoxazole derivatives targeting TACC3 as anticancer agents | A2A制药有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115279754-A | Isoxazole derivatives targeting TACC3 as anticancer agents | A2A制药有限公司 | 2022-11-01 | — | — | CN | disclosed |