Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914348 | 0.80 | KMT2A (0.39) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL29914341 | 0.80 | KMT2A (0.41) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL29914351 | 0.80 | KMT2A (0.39) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL22504981 | 0.68 | KMT2A (0.59) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL4464611 | 0.65 | SMN1; SMN2 (0.47) | CYP3A4CYP2C9KMT2ANPC1RAB9A | |
| SCHEMBL24590357 | 0.64 | MEN1 (0.55) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL23365218 | 0.64 | CYP3A4 (0.46) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL24590147 | 0.63 | KMT2A (0.54) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL23378499 | 0.63 | CYP3A4 (0.61) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL24590317 | 0.62 | MEN1 (0.53) | CYP3A4CYP2D6CYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279754-A | Isoxazole derivatives targeting TACC3 as anticancer agents | A2A制药有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115279754-A | Isoxazole derivatives targeting TACC3 as anticancer agents | A2A制药有限公司 | 2022-11-01 | — | — | CN | disclosed |