Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL299628 | 0.97 | TSHR (0.34) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| Hydrochloric Acid SCHEMBL299971 | 0.97 | TSHR (0.34) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL9960431 | 0.81 | CYP2D6 (0.35) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL16671651 | 0.79 | TSHR (0.35) | TSHRCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17311783 | 0.78 | TSHR (0.38) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL6050185 | 0.78 | TSHR (0.42) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL5983748 | 0.78 | CYP3A4 (0.40) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL5696068 | 0.78 | TSHR (0.38) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL410007 | 0.78 | TSHR (0.42) | TSHRCYP3A4TDP1MAPTCACNA1B | |
| SCHEMBL666513 | 0.78 | CYP3A4 (0.40) | TSHRCYP3A4TDP1MAPTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10036239-B2 | Graphene enhanced polymer composites and methods thereof | HALLIBURTON ENERGY SERVICES, INC. (US) | 2018-07-31 | — | — | US | claimed |
| US-9598631-B2 | Sulfonated relative permeability modifiers for reducing subterranean formation water permeability | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-03-21 | — | — | US | claimed |
| US-20170002262-A1 | SULFONATED RELATIVE PERMEABILITY MODIFIERS FOR REDUCING SUBTERRANEAN FORMATION WATER PERMEABILITY | HALIBURTON ENERGY SERVICES, INC. (US) | 2017-01-05 | — | — | US | claimed |
| US-20160340570-A1 | GRAPHENE ENHANCED POLYMER COMPOSITES AND METHODS THEREOF | HALLIBURTON ENERGY SERVICES INC. | 2016-11-24 | — | — | US | claimed |
| EP-1193365-B1 | Reducing subterranean formation water permeability | HALLIBURTON ENERGY SERV INC (US) | 2014-12-03 | — | — | EP | claimed |
| EP-2009076-A1 | Method for stimulating hydrocarbon production and reducing the production of water from a subterranean formation | Halliburton Energy Services, Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| US-7182136-B2 | Methods of reducing water permeability for acidizing a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2007-02-27 | — | — | US | claimed |
| US-20070012444-A1 | Apparatus and method for reducing water production from a hydrocarbon producing well | HALLIBURTON ENERGY SERVICES, INC. | 2007-01-18 | — | — | US | claimed |
| US-7114568-B2 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1644458-A1 | METHOD FOR STIMULATING HYDROCARBON PRODUCTION AND REDUCING THE PRODUCTION OF WATER FROM A SUBTERRANEAN FORMATION | Halliburton Energy Services, Inc. (US) | 2006-04-12 | — | — | EP | claimed |
| US-20050230114-A1 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. | 2005-10-20 | — | — | US | claimed |
| US-20050178549-A1 | Methods of reducing the permeabilities of horizontal well bore sections | HALLIBURTON ENERGY SERVICES, INC. | 2005-08-18 | — | — | US | claimed |
| WO-2005003515-A1 | METHODS OF REDUCING WATER PERMEABILITY FOR ACIDIZING A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| US-20050000694-A1 | Methods of reducing water permeability for acidizing a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004101706-A1 | METHOD FOR STIMULATING HYDROCARBON PRODUCTION AND REDUCING THE PRODUCTION OF WATER FROM A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2004-11-25 | — | — | WO | claimed |
| US-20040229756-A1 | Method for stimulating hydrocarbon production and reducing the production of water from a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-18 | — | — | US | claimed |
| US-6476169-B1 | Methods of reducing subterranean formation water permeability | HALLIBURTON ENERGY SERVICES, INC. | 2002-11-05 | — | — | US | claimed |
| EP-1193365-A1 | Reducing subterranean formation water permeability | Halliburton Energy Services, Inc. (US) | 2002-04-03 | — | — | EP | claimed |
| US-20230416598-A1 | ACIDIZING COMPOSITIONS FOR IMPROVED FLUID PERFORMANCE | HALLIBURTON ENERGY SERVICES, INC. (US) | 2023-12-28 | — | — | US | disclosed |
| EP-1193365-A1 | Reducing subterranean formation water permeability | Halliburton Energy Services, Inc. (US) | 2002-04-03 | — | — | EP | disclosed |