Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.39 |
| ▸ | ITGAL | P20701 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680880 | 1.00 | MAPK1 (0.44) | MAPK1MTORKCNH2PIK3CAPIK3CG | |
| SCHEMBL24680779 | 0.91 | ASIC3 (0.52) | MAPK1KCNH2ASIC3PARP10PARP11 | |
| SCHEMBL29914419 | 0.91 | ASIC3 (0.52) | MAPK1KCNH2ASIC3PARP10PARP11 | |
| SCHEMBL29914518 | 0.91 | MAPK1 (0.42) | MAPK1MTORKCNH2PIK3CAASIC3 | |
| SCHEMBL24681143 | 0.91 | MAPK1 (0.42) | MAPK1MTORKCNH2PIK3CAASIC3 | |
| SCHEMBL24680781 | 0.88 | MAPK1 (0.48) | MAPK1MTORKCNH2ASIC3PARP10 | |
| SCHEMBL29914564 | 0.88 | MAPK1 (0.48) | MAPK1MTORKCNH2ASIC3PARP10 | |
| SCHEMBL29964569 | 0.87 | ASIC3 (0.40) | MAPK1MTORPIK3CAPIK3CGASIC3 | |
| SCHEMBL24680849 | 0.87 | MAPK1 (0.55) | MAPK1MTORKCNH2PIK3CAASIC3 | |
| SCHEMBL24680722 | 0.85 | MAPK1 (0.52) | MAPK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |