Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681535 | 1.00 | CHEK2 (0.46) | CHEK2PIM1PIM3PIM2NOTUM | |
| SCHEMBL24681623 | 0.84 | NPY5R (0.43) | PIM1PIM3PIM2NOTUMNPY5R | |
| SCHEMBL29914608 | 0.84 | NPY5R (0.43) | PIM1PIM3PIM2NOTUMNPY5R | |
| SCHEMBL24681006 | 0.84 | NPY5R (0.43) | PIM1PIM3PIM2NOTUMNPY5R | |
| SCHEMBL29914569 | 0.84 | NPY5R (0.43) | PIM1PIM3PIM2NOTUMNPY5R | |
| SCHEMBL24681116 | 0.78 | PIM1 (0.39) | CHEK2PIM1PIM3PIM2KDM4E | |
| SCHEMBL29914606 | 0.78 | PIM1 (0.39) | CHEK2PIM1PIM3PIM2KDM4E | |
| SCHEMBL21448022 | 0.78 | NPY5R (0.51) | NOTUMEEDHRH1KCNH2KDM4E | |
| SCHEMBL17955710 | 0.76 | PIM1 (0.51) | CHEK2PIM1PIM3PIM2CHRM1 | |
| SCHEMBL31058329 | 0.76 | ROCK2 (0.38) | CHEK2PIM1PIM3PIM2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |