Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 15/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 14/20 | 0.40 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.33 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914483 | 0.84 | PARP10 (0.51) | PARP10PARP11PARP1ACHEPARP15 | |
| SCHEMBL29914538 | 0.82 | PARP10 (0.37) | PARP10PARP11PARP1ACHEF7 | |
| SCHEMBL24681129 | 0.82 | PARP10 (0.37) | PARP10PARP11PARP1ACHEF7 | |
| SCHEMBL22120086 | 0.80 | PARP1 (0.54) | PARP10PARP11PARP1ACHE | |
| SCHEMBL30905974 | 0.80 | PARP1 (0.54) | PARP10PARP11PARP1ACHE | |
| SCHEMBL22497740 | 0.80 | KDM4E (0.36) | — | |
| SCHEMBL24651189 | 0.80 | NOTUM (0.50) | — | |
| SCHEMBL29914536 | 0.73 | PARP10 (0.44) | PARP10PARP11PARP1F7F3 | |
| SCHEMBL23208842 | 0.71 | JAK2 (0.31) | — | |
| SCHEMBL29734746 | 0.71 | JAK2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |