Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914616 | 0.80 | PARP10 (0.40) | — | |
| SCHEMBL15144006 | 0.79 | MAOB (0.33) | MAPK1 | |
| SCHEMBL31707905 | 0.79 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDAPPAURKA | |
| SCHEMBL508291 | 0.79 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDAPPAURKA | |
| SCHEMBL23208842 | 0.76 | JAK2 (0.31) | JAK2BTK | |
| SCHEMBL17713762 | 0.76 | CYP11B1 (0.35) | JAK2BTK | |
| SCHEMBL29734746 | 0.76 | JAK2 (0.31) | JAK2BTK | |
| SCHEMBL10158544 | 0.73 | P2RX7 (0.37) | P2RX7MAPK1 | |
| SCHEMBL15132885 | 0.72 | MAPK1 (0.34) | P2RX7MAPK1 | |
| SCHEMBL748846 | 0.71 | OPRK1 (0.34) | ALDH1A1JAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113544129-A | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |