SCHEMBL299147

SCHEMBL299147

C=CCc1cc2ccccc2c(-c2ccccc2)c1N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AURKA O14965 1/20 0.38
DAPK3 O43293 1/20 0.38
MAP4K4 O95819 1/20 0.38
RET P07949 1/20 0.38
IGF1R P08069 1/20 0.38
MET P08581 1/20 0.38
PIM1 P11309 1/20 0.38
LTK P29376 1/20 0.38
KDR P35968 1/20 0.38
MAPK8 P45983 1/20 0.38
MAPK9 P45984 1/20 0.38
CDK8 P49336 1/20 0.38
CLK2 P49760 1/20 0.38
CDK9 P50750 1/20 0.38
CDK5 Q00535 1/20 0.38
ACVR1 Q04771 1/20 0.38
PTK2 Q05397 1/20 0.38
MAP4K2 Q12851 1/20 0.38
IKBKE Q14164 1/20 0.38
LRRK2 Q5S007 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28193331 0.88 AURKA (0.38) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL21215588 0.81 MEN1 (0.43) ALOX5ESR1ESR2KDM4EMAPT
SCHEMBL2184374 0.80 HTR2A (0.43) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL27798180 0.79 AURKA (0.39) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL4871725 0.78 AURKA (0.38) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL9088308 0.76 HTR2A (0.39) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL28222388 0.75 MEN1 (0.40) TLR8KDM4EMAPTMEN1KMT2A
SCHEMBL27947461 0.74 ESR1 (0.38) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL16487485 0.74 ESR1 (0.38) AURKADAPK3MAP4K4RETIGF1R
SCHEMBL11792710 0.73 TRPM4 (0.42) AURKADAPK3MAP4K4RETIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024115455-A1 HEAT-TRANSFER FLUIDS WITH LOW ELECTRICAL CONDUCTIVITY COMPRISING OXIME FUNCTIONALITY, METHODS FOR THEIR PREPARATION AND USES THEREOF Arteco N.v. (BE) 2024-06-06 WO disclosed
WO-2024115457-A1 HEAT-TRANSFER FLUIDS WITH LOW ELECTRICAL CONDUCTIVITY COMPRISING HYDROXYLAMINE OR OXIME FUNCTIONALITY, METHODS FOR THEIR PREPARATION AND USES THEREOF Arteco N.v. (BE) 2024-06-06 WO disclosed
EP-4363518-A1 HEAT-TRANSFER FLUID WITH LOW ELECTRICAL CONDUCTIVITY COMPRISING A VINYL PYRROLIDONE POLYMER, METHODS FOR ITS PREPARATION AND USES THEREOF Arteco NV (BE) 2024-05-08 EP disclosed
EP-3986974-B1 SILICATE BASED HEAT TRANSFER FLUID, METHODS OF ITS PREPARATIONS AND USES THEREOF ARTECO NV (BE) 2023-07-26 EP disclosed
US-20230099572-A1 Heat-transfer fluid with low conductivity comprising an amide inhibitor, methods for its preparation and uses thereof Arteco N.v. (BE) 2023-03-30 US disclosed
WO-2023275016-A1 HEAT-TRANSFER FLUID WITH LOW ELECTRICAL CONDUCTIVITY COMPRISING A VINYL PYRROLIDONE POLYMER, METHODS FOR ITS PREPARATION AND USES THEREOF ARTECO NV (BE) 2023-01-05 WO disclosed
EP-4103659-A1 HEAT-TRANSFER FLUID WITH LOW CONDUCTIVITY COMPRISING AN AMIDE INHIBITOR, METHODS FOR ITS PREPARATION AND USES THEREOF ARTECO N.V. (BE) 2022-12-21 EP disclosed
EP-4017933-A1 GLYCOL BASED HEAT-TRANSFER FLUID COMPRISING ORGANIC CARBOXYLIC ACID OR SALT THEREOF, METHODS FOR ITS PREPARATIONS AND USES THEREOF Arteco NV (BE) 2022-06-29 EP disclosed
EP-3986974-A1 SILICATE BASED HEAT TRANSFER FLUID, METHODS OF ITS PREPARATIONS AND USES THEREOF Arteco NV (BE) 2022-04-27 EP disclosed
WO-2021160674-A1 HEAT-TRANSFER FLUID WITH LOW CONDUCTIVITY COMPRISING AN AMIDE INHIBITOR, METHODS FOR ITS PREPARATION AND USES THEREOF ARTECO NV (BE) 2021-08-19 WO disclosed
EP-2171014-A1 ANTIFREEZE CONCENTRATE AND COOLANT COMPOSITIONS AND PREPARATION THEREOF Chevron U.S.A., Inc. (US) 2010-04-07 EP disclosed
US-20090250654-A1 ANTIFREEZE CONCENTRATE AND COOLANT COMPOSITIONS AND PREPARATION THEREOF CHEVRON U.S.A. INC. 2009-10-08 US disclosed
US-20090146100-A1 ANTIFREEZE CONCENTRATE AND COOLANT COMPOSITIONS AND PREPARATION THEREOF CHEVRON U.S.A. INC. 2009-06-11 US disclosed
WO-2009035741-A1 ANTIFREEZE CONCENTRATE AND COOLANT COMPOSITIONS AND PREPARATION THEREOF CHEVRON U.S.A INC. (US) 2009-03-19 WO disclosed
WO-2009006128-A1 ANTIFREEZE CONCENTRATE AND COOLANT COMPOSITIONS AND PREPARATION THEREOF CHEVRON U.S.A. INC. (US) 2009-01-08 WO disclosed
US-20090001313-A1 Antifreeze Concentrate and Coolant Compositions and Preparation Thereof CHEVRON U.S.A. INC. (US) 2009-01-01 US disclosed
US-20090001312-A1 Antifreeze Concentrate and Coolant Compositions and Preparation Thereof CHEVRON U.S.A. INC. (US) 2009-01-01 US disclosed
US-20040046146-A1 Complex esters for use with fluorinated refrigerants NESTE CHEMICALS OY 2004-03-11 US disclosed
US-6436309-B1 COMPRISING MIXTURES OF HYDROFLUOROCARBONS AND OXY ESTERS, USED AS LUBRICANT OILS FOR AUTOMOBILES, AIRCRAFTS AND TURBINES; SOLUBILITY FORTUM OIL AND GAS OY (FI) 2002-08-20 US disclosed
US-20020036283-A1 Complex esters for use with fluorinated refrigerants NESTE CHEMICALS OY 2002-03-28 US disclosed