Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | S100A9 | P06702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582693 | 1.00 | HTR6 (0.52) | HTR6EGFRALOX15HTTFFAR2 | |
| SCHEMBL31375066 | 0.88 | S100A9 (0.44) | HTR6EGFRALOX15HTTPOLB | |
| SCHEMBL31109019 | 0.82 | POLB (0.54) | EGFRALOX15HTTPOLBHCAR2 | |
| SCHEMBL7971906 | 0.78 | HTR6 (0.52) | HTR6HTTFFAR2HCAR2PRMT5 | |
| SCHEMBL19880218 | 0.78 | HTR6 (0.52) | HTR6HTTPOLBPRMT5WDR77 | |
| SCHEMBL17589590 | 0.78 | CYP11B1 (0.54) | HTR6HTTPOLBHCAR2PRMT5 | |
| SCHEMBL114613 | 0.78 | HTR6 (0.52) | HTR6FFAR2POLBPRMT5WDR77 | |
| SCHEMBL29945255 | 0.76 | HTR6 (0.61) | HTR6EGFRPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL3831593 | 0.76 | HTR6 (0.61) | HTR6EGFRPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL12909455 | 0.76 | FEN1 (0.45) | EGFRALOX15HTTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | disclosed |