Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22613643 | 0.88 | TGFBR1 (0.41) | MAPTTGFBR1MAPK14SMN1; SMN2MEN1 | |
| SCHEMBL29915313 | 0.84 | MAPT (0.40) | MAPTTGFBR1MAPK14SMN1; SMN2MEN1 | |
| SCHEMBL29915324 | 0.83 | MAPT (0.43) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL20600076 | 0.83 | MAPK14 (0.46) | MAPTTGFBR1MAPK14SMN1; SMN2ADORA2A | |
| SCHEMBL20600283 | 0.82 | MAPK14 (0.47) | MAPTTGFBR1MAPK14SMN1; SMN2MEN1 | |
| SCHEMBL29915423 | 0.82 | MAPT (0.46) | MAPTSMN1; SMN2MEN1KMT2AADORA2A | |
| SCHEMBL29915381 | 0.81 | MAPT (0.41) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL29915468 | 0.80 | PTGDR (0.42) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL20600390 | 0.78 | MAPT (0.69) | MAPTTGFBR1MAPK14SMN1; SMN2 | |
| SCHEMBL29915535 | 0.77 | MAPT (0.41) | MAPTSMN1; SMN2MEN1KMT2ACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | Recordati Industria Chimica e Farmacentica S.p.A. (IT) | 2022-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11440922-B2 | Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors | GRM5, GRIK5, GRM2 | MAPT 361/4885TGFBR1 2248/4885MAPK14 1054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.