Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 4/20 | 0.33 |
| ▸ | FLT4 | P35916 | 4/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17647642 | 1.00 | ITGB3 (0.37) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL29917902 | 0.92 | ITGB3 (0.37) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL17648682 | 0.92 | ITGB3 (0.37) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL17648601 | 0.90 | FLT1 (0.35) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL29916998 | 0.90 | FLT1 (0.35) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL17649370 | 0.89 | ITGB3 (0.34) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL29917273 | 0.89 | ITGB3 (0.34) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL17647992 | 0.88 | ITGB3 (0.39) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL29916260 | 0.88 | ITGB3 (0.39) | ITGB3ITGAVITGA2BFLT1FLT4 | |
| SCHEMBL19439884 | 0.87 | LGALS8 (0.36) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |