Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17649366 | 1.00 | PTGS2 (0.48) | PTGS2PTGS1EGFRPPARGPKM | |
| SCHEMBL29915847 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL17647695 | 0.88 | PTGS2 (0.50) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL29917888 | 0.87 | KIF18A (0.41) | PTGS2PTGS1EGFRPPARGFLT1 | |
| SCHEMBL17647883 | 0.87 | KIF18A (0.41) | PTGS2PTGS1EGFRPPARGFLT1 | |
| SCHEMBL29915808 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL17647834 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL17647991 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL29916780 | 0.85 | FLT1 (0.54) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL17649941 | 0.85 | FLT1 (0.54) | PTGS2PTGS1EGFRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |