Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846996 | 1.00 | PDE10A (0.31) | PDE10A | |
| SCHEMBL10853509 | 0.94 | ALDH1A1 (0.32) | PDE10A | |
| SCHEMBL10847567 | 0.92 | ALDH1A1 (0.35) | PDE10A | |
| SCHEMBL30488589 | 0.92 | ALDH1A1 (0.35) | PDE10A | |
| SCHEMBL29919401 | 0.88 | PDE10A (0.39) | PDE10A | |
| SCHEMBL1787799 | 0.88 | PDE10A (0.39) | PDE10A | |
| SCHEMBL31091209 | 0.88 | PDE10A (0.39) | PDE10A | |
| SCHEMBL16577352 | 0.78 | PDE10A (0.36) | PDE10A | |
| SCHEMBL7594171 | 0.75 | — | — | |
| SCHEMBL25153045 | 0.72 | PDE10A (0.46) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022216655-A1 | N-(6-((OCTAHYDROCYCLOPENTA[C]PYRROL-5-YI)AMINO)PYRIDAZIN-3-YL)PHENYL)CARBOXAMIDE AND (6- ((OCTAHYDROCYCLOPENTA[C]PYRROL-5-YL)AMINO)PYRIDAZIN-3-YL)BENZAMIDE DERIVATIVES AS MACHR M4 ANTAGONISTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | VANDERBILT UNIVERSITY (US) | 2022-10-13 | — | — | WO | disclosed |
| WO-2022212819-A1 | INDAZOLE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |