Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895276 | 0.80 | GRM2 (0.47) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL8004566 | 0.78 | CYP2C19 (0.52) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL848416 | 0.76 | CYP2C19 (0.50) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL12971036 | 0.76 | TSHR (0.46) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL28961022 | 0.74 | GRM2 (0.50) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL7036505 | 0.74 | GRM2 (0.50) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL15741164 | 0.74 | TSHR (0.45) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL27691317 | 0.74 | GRM4 (0.56) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL18199 | 0.74 | TSHR (0.45) | TSHRLMNAGRM2GRM3GRM4 | |
| SCHEMBL4443561 | 0.74 | APLNR (0.56) | TSHRLMNAGRM2GRM3GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957357-A | Aminoglycoside derivatives and their use in the treatment of genetic disorders | ELOXX制药有限公司 | 2022-08-30 | — | — | CN | disclosed |