Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823315 | 0.95 | ALDH1A1 (0.56) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL22499335 | 0.89 | KDM4E (0.57) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL22499322 | 0.87 | KDM4E (0.56) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10163632 | 0.80 | KDM4E (0.48) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8247383 | 0.80 | KDM4E (0.48) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL24691325 | 0.79 | KDM4E (0.56) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4257194 | 0.76 | ALDH1A1 (0.50) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL29918948 | 0.76 | METTL3 (0.54) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL22499324 | 0.76 | METTL3 (0.57) | KDM4EMAPTSMN1; SMN2ALDH1A1METTL3 | |
| Lithium Ion SCHEMBL22499045 | 0.75 | METTL3 (0.53) | KDM4EHPGDMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022254216-A1 | COMBINATION THERAPIES COMPRISING A METTL3 INHIBITOR AND A FURTHER ANTICANCER AGENT | STORM THERAPEUTICS LTD (GB) | 2022-12-08 | — | — | WO | disclosed |
| EP-4069694-A1 | POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS | Storm Therapeutics Ltd (GB) | 2022-10-12 | — | — | EP | disclosed |