Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185547 | 1.00 | CYP11B1 (0.49) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL29207918 | 0.84 | KDM4E (0.40) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL24534060 | 0.82 | CYP11B1 (0.42) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL3507833 | 0.82 | CYP11B1 (0.42) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL3749196 | 0.82 | CYP11B1 (0.43) | CYP11B1CYP11B2SLC22A12CYP3A4CYP2C9 | |
| SCHEMBL30964464 | 0.79 | CYP11B1 (0.40) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL15463724 | 0.79 | NR1H2 (0.40) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL24533960 | 0.77 | CYP11B1 (0.39) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL2732538 | 0.76 | CYP1A2 (0.39) | CYP11B1CYP11B2SLC22A12POLBHCAR2 | |
| SCHEMBL5160 | 0.76 | CYP11B1 (0.61) | CYP11B1CYP11B2S1PR1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024165050-A1 | PROTEOLYSIS-TARGETING CHIMERA (PROTAC) COMPOUNDS AND USES THEREOF FIELD | AUBRAK THERAPEUTICS (CN) | 2024-08-15 | — | — | WO | disclosed |
| CN-117751115-A | Compounds, compositions, and methods of treating cancer | 热点治疗公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4323358-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER | Hotspot Therapeutics, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221704-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER | HOTSPOT THERAPEUTICS, INC. (US) | 2022-10-20 | — | — | WO | disclosed |