SCHEMBL185547

SCHEMBL185547

FC(F)(F)c1cncc(Br)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 4/20 0.49
CYP11B2 P19099 4/20 0.49
SLC22A12 Q96S37 2/20 0.41
POLB P06746 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
SLC22A6 Q4U2R8 1/20 0.38
SLC22A8 Q8TCC7 1/20 0.38
SLC22A11 Q9NSA0 1/20 0.38
PRKAB2 O43741 1/20 0.38
PRKAG1 P54619 1/20 0.38
PRKAA2 P54646 1/20 0.38
PRKAA1 Q13131 1/20 0.38
PRKAG3 Q9UGI9 1/20 0.38
PRKAG2 Q9UGJ0 1/20 0.38
PRKAB1 Q9Y478 1/20 0.38
HDAC4 P56524 1/20 0.36
DAO P14920 1/20 0.36
S1PR1 P21453 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29920114 1.00 CYP11B1 (0.49) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL29207918 0.84 KDM4E (0.40) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL24534060 0.82 CYP11B1 (0.42) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL3507833 0.82 CYP11B1 (0.42) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL3749196 0.82 CYP11B1 (0.43) CYP11B1CYP11B2SLC22A12CYP3A4CYP2C9
SCHEMBL30964464 0.79 CYP11B1 (0.40) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL15463724 0.79 NR1H2 (0.40) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL24533960 0.77 CYP11B1 (0.39) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL2732538 0.76 CYP1A2 (0.39) CYP11B1CYP11B2SLC22A12POLBHCAR2
SCHEMBL5160 0.76 CYP11B1 (0.61) CYP11B1CYP11B2S1PR1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 723 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747247-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF Apogee Pharmaceuticals, Inc. (CA) 2026-05-27 EP disclosed
CN-122079983-A FGFR3 inhibitor compounds 2026-05-26 CN disclosed
CN-122079985-A FGFR3 inhibitor compounds 2026-05-26 CN disclosed
CN-122079984-A FGFR3 inhibitor compounds 2026-05-26 CN disclosed
CN-117659017-B TRPML1/2 modulator compound, pharmaceutical composition, preparation method and application thereof 北京华益健康药物研究中心 2026-05-15 CN disclosed
EP-4073062-B1 FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) RYVU THERAPEUTICS S A (PL) 2026-04-29 EP disclosed
US-12612380-B2 Non-lysosomal glucosylceramidase inhibitors and uses thereof ALECTOS THERAPEUTICS 1NC (CA) 2026-04-28 US disclosed
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 EP disclosed
US-12583815-B2 Inhibitors of YAP/TAZ-TEAD oncoproteins, synthesis and use thereof BRIDGENE BIOSCIENCES, INC. (US) 2026-03-24 US disclosed
EP-3966199-B1 NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF ALECTOS THERAPEUTICS INC (CA) 2026-03-18 EP disclosed
EP-1270582-B1 TRIPHENYLPHOSPHINE DERIVATIVES, PALLADIUM OR NICKEL COMPLEXES THEREOF, AND PROCESS FOR PREPARING BIARYL DERIVATIVES MITSUBISHI RAYON CO (JP) 2006-08-30 EP disclosed
US-20060160857-A1 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. 2006-07-20 US disclosed
WO-2006074884-A1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2006-07-20 WO disclosed
US-20060020133-A1 3-aminocyclopentanecarboxamides as modulators of chemokine receptors INCYTE CORPORATION 2006-01-26 US disclosed
WO-2006004741-A2 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2006-01-12 WO disclosed
WO-2006004684-A2 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2006-01-12 WO disclosed
US-20060004018-A1 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors INCYTE CORPORATION 2006-01-05 US disclosed
US-6693210-B2 USING PALLADIUM, NICKEL PHOSPHINE COMPLEX AS CATALYSTS MITSUBISHI RAYON CO., LTD. (JP) 2004-02-17 US disclosed
US-20030065208-A1 Using palladium, nickel phosphine complex as catalysts MITSUBISHI RAYON CO., LTD. (JP) 2003-04-03 US disclosed
EP-1270582-A1 TRIPHENYLPHOSPHINE DERIVATIVE, PRODUCTION PROCESS THEREFOR, PALLADIUM COMPLEX THEREOF, AND PROCESS FOR PRODUCING BIARYL DERIVATIVE Mitsubishi Rayon Co., Ltd. (JP) 2003-01-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583815-B2 Inhibitors of YAP/TAZ-TEAD oncoproteins, synthesis and use thereof YAP1, TEAD1, TEAD2 CYP11B1 3753/4885CYP11B2 4093/4885SLC22A12 2603/4885
US-20060160857-A1 Thiazole-4-carboxyamide derivatives GRM1, GRM2, GRIA4 CYP11B1 2677/4885CYP11B2 2665/4885SLC22A12 982/4885
US-20030065208-A1 Using palladium, nickel phosphine complex as catalysts PDCD1LG2, PIK3CA, PDCD1 CYP11B1 1690/4885CYP11B2 1264/4885SLC22A12 4178/4885
US-20060020133-A1 3-aminocyclopentanecarboxamides as modulators of chemokine receptors CCR5, ACKR3, CXCR3 CYP11B1 858/4885CYP11B2 901/4885SLC22A12 618/4885
US-20060004018-A1 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors CCR5, ACKR3, CXCR3 CYP11B1 858/4885CYP11B2 901/4885SLC22A12 618/4885
US-12612380-B2 Non-lysosomal glucosylceramidase inhibitors and uses thereof GBA1, GBA2, MAN2B1 CYP11B1 4261/4885CYP11B2 4349/4885SLC22A12 1285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.