Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24198751 | 0.87 | NNMT (0.40) | NNMTPOLBAPEX1ALDH1A1NAPRT | |
| SCHEMBL13304188 | 0.77 | NNMT (0.43) | NNMTPOLBALDH1A1NAPRTSIRT6 | |
| SCHEMBL29562604 | 0.77 | NNMT (0.43) | NNMTPOLBALDH1A1NAPRTSIRT6 | |
| SCHEMBL16333365 | 0.77 | NNMT (0.42) | NNMTALDH1A1NAPRTSIRT6MEN1 | |
| SCHEMBL29577063 | 0.77 | NNMT (0.42) | NNMTALDH1A1NAPRTSIRT6MEN1 | |
| SCHEMBL28662886 | 0.77 | NNMT (0.42) | NNMTNAPRTSIRT6MEN1KMT2A | |
| SCHEMBL30726361 | 0.76 | ATR (0.43) | NNMTKMT2AATRCNR2 | |
| SCHEMBL18298896 | 0.76 | ATR (0.43) | NNMTKMT2AATRCNR2 | |
| SCHEMBL625580 | 0.75 | SMN1; SMN2 (0.47) | NNMTALDH1A1NAPRTSIRT6MEN1 | |
| SCHEMBL29446081 | 0.75 | SMN1; SMN2 (0.47) | NNMTALDH1A1NAPRTSIRT6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188735-A1 | HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-09-15 | — | — | WO | disclosed |