Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.67 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.66 |
| ▸ | MTOR | P42345 | 7/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.63 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.63 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.63 |
| ▸ | PRKDC | P78527 | 1/20 | 0.63 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21469915 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3C3MTORAKT1 | |
| SCHEMBL21469752 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3R1MTORAKT1 | |
| SCHEMBL29923130 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3R1MTORAKT1 | |
| SCHEMBL17859781 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3C3MTORPIK3CG | |
| SCHEMBL1310732 | 0.80 | MTOR (0.76) | PIK3CAPIK3R1PIK3C3MTORPIK3CG | |
| SCHEMBL21465338 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3C3MTORAKT1 | |
| SCHEMBL29366652 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3C3MTORAKT1 | |
| SCHEMBL7914669 | 0.79 | MTOR (0.81) | PIK3CAPIK3R1PIK3C3MTORPIK3CG | |
| SCHEMBL21464219 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3C3MTORAKT1 | |
| SCHEMBL29923007 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3C3MTORAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637450-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | GLOBAL CANCER TECHNOLOGY INC. (US) | 2026-05-26 | — | — | US | disclosed |
| US-20240327396-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2024-10-03 | — | — | US | disclosed |
| US-12049462-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | NEUROPORE THERAPIES, INC. (US) | 2024-07-30 | — | — | US | disclosed |
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | NEUROPORE THERAPIES, INC. (US) | 2022-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | ATG7, ULK1, BECN1 | PIK3CA 31/4885PIK3R1 8/4885PIK3C3 52/4885 |
| US-12637450-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | PIK3R4, PIK3R1, ATG7 | PIK3CA 52/4885PIK3R1 2/4885PIK3C3 61/4885 |
| US-20240327396-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885PIK3R1 8/4885PIK3C3 52/4885 |
| US-12049462-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | ATG7, ULK1, BECN1 | PIK3CA 31/4885PIK3R1 8/4885PIK3C3 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.