Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.81 |
| ▸ | JAK2 | O60674 | 5/20 | 0.81 |
| ▸ | JAK1 | P23458 | 5/20 | 0.81 |
| ▸ | JAK3 | P52333 | 5/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359040 | 1.00 | TYK2 (0.81) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552183 | 0.90 | TYK2 (0.85) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28359087 | 0.89 | TYK2 (1.00) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922629 | 0.89 | TYK2 (0.64) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28359080 | 0.89 | TYK2 (0.64) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28362763 | 0.83 | JAK2 (0.59) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922544 | 0.83 | JAK2 (0.59) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552247 | 0.82 | TYK2 (0.56) | TYK2JAK2JAK1JAK3DGAT1 | |
| SCHEMBL29922630 | 0.82 | TYK2 (0.54) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922581 | 0.81 | JAK2 (0.52) | TYK2JAK2JAK1JAK3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |