Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 12/20 | 0.36 |
| ▸ | JAK1 | P23458 | 11/20 | 0.36 |
| ▸ | TYK2 | P29597 | 11/20 | 0.36 |
| ▸ | JAK2 | O60674 | 10/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922756 | 0.79 | JAK2 (0.40) | JAK3JAK1TYK2JAK2BTK | |
| SCHEMBL29922608 | 0.79 | JAK2 (0.39) | JAK3JAK1TYK2JAK2 | |
| SCHEMBL29922762 | 0.79 | JAK2 (0.46) | JAK3JAK1TYK2JAK2 | |
| SCHEMBL29922701 | 0.79 | JAK2 (0.41) | MKNK1JAK3JAK1TYK2JAK2 | |
| SCHEMBL29922684 | 0.78 | TYK2 (0.40) | JAK3JAK1TYK2JAK2LRRK2 | |
| SCHEMBL29922798 | 0.77 | JAK3 (0.52) | JAK3JAK1TYK2JAK2PIM1 | |
| SCHEMBL29922883 | 0.77 | TYK2 (0.40) | JAK3JAK1TYK2JAK2BTK | |
| SCHEMBL29922706 | 0.77 | JAK2 (0.43) | JAK3JAK1TYK2JAK2LRRK2 | |
| SCHEMBL28362822 | 0.76 | JAK2 (0.54) | MKNK1MKNK2JAK3JAK1TYK2 | |
| SCHEMBL29922700 | 0.76 | JAK2 (0.43) | JAK3JAK1TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |