Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PRF1 | P14222 | 6/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | UGCG | Q16739 | 2/20 | 0.34 |
| ▸ | MYLK | Q15746 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922756 | 0.86 | JAK2 (0.40) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL28362689 | 0.81 | JAK2 (0.51) | JAK2KITFLT3MKNK1PARP1 | |
| SCHEMBL29922888 | 0.79 | MKNK1 (0.37) | JAK2MKNK1JAK1TYK2JAK3 | |
| SCHEMBL29922592 | 0.78 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922762 | 0.75 | JAK2 (0.46) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922608 | 0.75 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29552095 | 0.74 | JAK2 (0.51) | JAK2KITFLT3MKNK1PIK3CA | |
| SCHEMBL29922684 | 0.74 | TYK2 (0.40) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922887 | 0.73 | JAK1 (0.40) | JAK2FLT3JAK1TYK2JAK3 | |
| SCHEMBL29922706 | 0.72 | JAK2 (0.43) | JAK2JAK1TYK2JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |