Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.40 |
| ▸ | JAK1 | P23458 | 10/20 | 0.40 |
| ▸ | TYK2 | P29597 | 10/20 | 0.40 |
| ▸ | JAK3 | P52333 | 10/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922701 | 0.86 | JAK2 (0.41) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922883 | 0.80 | TYK2 (0.40) | JAK2JAK1TYK2JAK3DYRK1A | |
| SCHEMBL29922592 | 0.80 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922888 | 0.79 | MKNK1 (0.37) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922608 | 0.79 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922762 | 0.79 | JAK2 (0.46) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL28358955 | 0.78 | JAK2 (0.57) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922684 | 0.78 | TYK2 (0.40) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922574 | 0.77 | JAK2 (0.48) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL29922700 | 0.76 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |