Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.33 |
| ▸ | GLRB | P48167 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377054 | 1.00 | KDM4E (0.40) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL22408771 | 0.93 | KDM4E (0.36) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL376917 | 0.87 | KDM4E (0.34) | KDM4EHPGDHSD17B10GAAALDH1A1 | |
| SCHEMBL1789205 | 0.86 | KDM4E (0.44) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL19438402 | 0.86 | CFTR (0.38) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL19438426 | 0.86 | CUL4A (0.38) | KDM4EHPGDHSD17B10LMNATP53 | |
| SCHEMBL19438424 | 0.86 | CUL4A (0.44) | KDM4EHPGDHSD17B10CYP3A4GAA | |
| SCHEMBL784720 | 0.85 | KDM4E (0.35) | KDM4EHPGDHSD17B10 | |
| SCHEMBL17875115 | 0.84 | KDM4E (0.34) | KDM4EHPGDHSD17B10GAAALDH1A1 | |
| SCHEMBL16154614 | 0.84 | VCAM1 (0.38) | KDM4EHPGDHSD17B10LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240270694-A1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND NOVEL SOLVATES THEREOF | RK PHARMA INC. (US) | 2024-08-15 | — | — | US | disclosed |
| WO-2022148822-A1 | USP5 BINDING SURVIVAL-TARGETING CHIMERIC (SURTAC) MOLECULES & USES THEREOF | LOCKI THERAPEUTICS LIMITED (GB) | 2022-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270694-A1 | PROCESS FOR THE PREPARATION OF IVACAFTOR AND NOVEL SOLVATES THEREOF | SLC10A2, SLC10A1, AVPR2 | KDM4E 1551/4885HPGD 2489/4885HSD17B10 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.