Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916320 | 1.00 | CSNK2A1 (0.33) | CSNK2A1HIPK2HTR1AADRA1DADRA1A | |
| SCHEMBL27167395 | 0.82 | PDE10A (0.34) | HTR1AADRA1DADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL27167385 | 0.80 | CSNK2A1 (0.35) | CSNK2A1HIPK2NSD2CASP6SMN1; SMN2 | |
| SCHEMBL24916023 | 0.80 | BCL2L11 (0.33) | HTR1AADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL25130855 | 0.79 | CSNK2A1 (0.34) | CSNK2A1HIPK2NSD2CASP6SMN1; SMN2 | |
| SCHEMBL27167379 | 0.78 | CRHR1 (0.33) | MBOAT4NOS3NOS2KDM4EHTT | |
| SCHEMBL30054192 | 0.78 | CRHR1 (0.33) | MBOAT4NOS3NOS2KDM4EHTT | |
| SCHEMBL29923376 | 0.74 | PDE10A (0.41) | SMN1; SMN2KDM4EMEN1TP53HSP90AA1 | |
| SCHEMBL30056847 | 0.73 | CDC7 (0.41) | SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL27167368 | 0.73 | CDC7 (0.41) | SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334305-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236101-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2022-11-10 | — | — | WO | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |