Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 6/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24915779 | 1.00 | MAPT (0.45) | MAPTALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL24916325 | 0.79 | BACE1 (0.47) | MAPTALDH1A1HPGDLMNANQO2 | |
| SCHEMBL29923623 | 0.79 | BACE1 (0.47) | MAPTALDH1A1HPGDLMNANQO2 | |
| SCHEMBL29923356 | 0.78 | MAPT (0.46) | MAPTALDH1A1PRNPNPSR1RXFP1 | |
| SCHEMBL24916334 | 0.78 | MAPT (0.46) | MAPTALDH1A1PRNPNPSR1RXFP1 | |
| SCHEMBL24915597 | 0.78 | BCL2L11 (0.42) | MAPTHPGDLMNASMN1; SMN2NQO2 | |
| SCHEMBL23208763 | 0.78 | RXFP1 (0.46) | MAPTALDH1A1PRNPNPSR1RXFP1 | |
| SCHEMBL24951537 | 0.74 | KDM4E (0.49) | MAPTALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL24915844 | 0.73 | GRM1 (0.45) | MAPTALDH1A1HPGDSMN1; SMN2RXFP1 | |
| SCHEMBL29923867 | 0.73 | GRM1 (0.45) | MAPTALDH1A1HPGDSMN1; SMN2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |