SCHEMBL29924530

SCHEMBL29924530

Cc1nc2ccc(C(=O)O)cc2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 1.00
HSP90AA1 P07900 1/20 1.00
ESR2 Q92731 1/20 1.00
ALDH1A1 P00352 3/20 0.72
POLB P06746 3/20 0.72
SMN1; SMN2 Q16637 2/20 0.72
RAB9A P51151 2/20 0.72
HPGD P15428 1/20 0.72
NPSR1 Q6W5P4 1/20 0.60
APEX1 P27695 1/20 0.57
NR4A2 P43354 1/20 0.56
CHEK2 O96017 3/20 0.55
MAPK1 P28482 1/20 0.55
EGLN1 Q9GZT9 1/20 0.54
PIN1 Q13526 1/20 0.53
TOP2A P11388 1/20 0.52
MLKL Q8NB16 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758956 1.00 TDP1 (1.00) TDP1HSP90AA1ESR2ALDH1A1POLB
Hydrochloric Acid SCHEMBL7331913 0.98 TDP1 (0.97) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL14669315 0.89 HSP90AA1 (0.78) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL23226713 0.87 HSP90AA1 (0.77) TDP1HSP90AA1ESR2ALDH1A1POLB
Guanidine SCHEMBL8688492 0.86 HSP90AA1 (0.74) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL6113137 0.86 HSP90AA1 (0.76) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL1106071 0.86 TDP1 (0.76) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL7428472 0.85 HSP90AA1 (0.73) TDP1HSP90AA1ESR2ALDH1A1POLB
Hydrochloric Acid SCHEMBL7331906 0.85 TDP1 (0.73) TDP1HSP90AA1ESR2ALDH1A1POLB
SCHEMBL12909208 0.84 ALDH1A1 (1.00) TDP1HSP90AA1ESR2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023029380-A1 NOVEL ARYL ETHER SUBSTITUTED HETEROCYCLIC COMPOUND AS GLP1R AGONIST 杭州德睿智药科技有限公司 2023-03-09 WO disclosed
WO-2022228490-A1 POLYCYCLIC DERIVATIVE MODULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2022-11-03 WO disclosed