Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | ABL1 | P00519 | 4/20 | 0.69 |
| ▸ | FABP6 | P51161 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | XIAP | P98170 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL29258949 | 0.96 | ALDH1A1 (0.92) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL23900204 | 0.89 | POLB (0.81) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1108966 | 0.88 | ALDH1A1 (0.78) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL25931738 | 0.87 | POLB (0.76) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL23867566 | 0.87 | POLB (0.76) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL12981224 | 0.86 | ALDH1A1 (0.75) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL16927680 | 0.84 | ALDH1A1 (0.72) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1758956 | 0.84 | TDP1 (1.00) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL29924530 | 0.84 | TDP1 (1.00) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7331913 | 0.83 | TDP1 (0.97) | ALDH1A1POLBHPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018178-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT OR ANTI-VIRUS AGENT COMPRISING THE SAME | BIOMETRIX TECHNOLOGY INC (KR) | 2024-01-18 | — | — | US | disclosed |
| US-20230248702-A1 | MICELLE COMPRISING BENZIMIDAZOLE-CARBOHYDRATE CONJUGATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTICANCER AGENT OR ANTIVIRAL AGENT COMPRISING THE SAME | BIOMETRIX TECHNOLOGY INC. (KP) | 2023-08-10 | — | — | US | disclosed |
| US-20230248702-A1 | MICELLE COMPRISING BENZIMIDAZOLE-CARBOHYDRATE CONJUGATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTICANCER AGENT OR ANTIVIRAL AGENT COMPRISING THE SAME | BIOMETRIX TECHNOLOGY INC. (KP) | 2023-08-10 | — | — | US | disclosed |
| US-11667661-B2 | Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same | BIOMETRIX TECHNOLOGY INC (KR) | 2023-06-06 | — | — | US | disclosed |
| US-20210395289-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT OR ANTI-VIRUS AGENT COMPRISING THE SAME | BIOMETRIX TECHNOLOGY INC (KR) | 2021-12-23 | — | — | US | disclosed |
| EP-3907230-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT COMPRISING THE SAME | Biometrix Technology Inc. (KR) | 2021-11-10 | — | — | EP | disclosed |
| WO-2021201352-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF AS ANTICANCER AGENT | (주)바이오메트릭스 테크놀로지 | 2021-10-07 | — | — | WO | disclosed |
| US-20210300959-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT COMPRISING THE SAME | BIOMETRIX TECHNOLOGY INC (KR) | 2021-09-30 | — | — | US | disclosed |
| US-20160115136-A1 | COMPOUNDS, COMPOSITIONS COMPRSING SAME, AND METHODS RELATED THERETO | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| US-8338594-B2 | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase | BAYER HEALTHCARE LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110021518-A1 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE | BAYER HEALTHCARE LLC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395289-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT OR ANTI-VIRUS AGENT COMPRISING THE SAME | ZC3HAV1, DDX41, ZC3HAV1L | ALDH1A1 480/4885POLB 636/4885HPGD 3935/4885 |
| US-20160115136-A1 | COMPOUNDS, COMPOSITIONS COMPRSING SAME, AND METHODS RELATED THERETO | LPO, NOTUM, FARS2 | ALDH1A1 1503/4885POLB 1245/4885HPGD 588/4885 |
| US-20210300959-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT COMPRISING THE SAME | H1-3, H1-4, H1-5 | ALDH1A1 136/4885POLB 3975/4885HPGD 4529/4885 |
| US-20230248702-A1 | MICELLE COMPRISING BENZIMIDAZOLE-CARBOHYDRATE CONJUGATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTICANCER AGENT OR ANTIVIRAL AGENT COMPRISING THE SAME | RB1, CCNI, CA14 | ALDH1A1 1676/4885POLB 2931/4885HPGD 4596/4885 |
| US-20240018178-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT OR ANTI-VIRUS AGENT COMPRISING THE SAME | ZC3HAV1, DDX41, ZC3HAV1L | ALDH1A1 480/4885POLB 636/4885HPGD 3935/4885 |
| US-11667661-B2 | Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same | H1-3, H1-4, H1-5 | ALDH1A1 142/4885POLB 4119/4885HPGD 4431/4885 |
| US-20110021518-A1 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE | AURKC, AURKA, PLK1 | ALDH1A1 3546/4885POLB 697/4885HPGD 1776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.