Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 13/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 13/20 | 0.38 |
| ▸ | F11 | P03951 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244671 | 1.00 | LPL (0.38) | LPLLIPGF11FFAR1HCAR1 | |
| SCHEMBL28628663 | 0.86 | LPL (0.44) | LPLLIPGF11FFAR1F2 | |
| SCHEMBL16426120 | 0.86 | LPL (0.44) | LPLLIPGF11FFAR1F2 | |
| SCHEMBL18015340 | 0.86 | LPL (0.44) | LPLLIPGF11FFAR1EGFR | |
| SCHEMBL587884 | 0.86 | LPL (0.44) | LPLLIPGF11EGFRCA1 | |
| SCHEMBL22179707 | 0.79 | LPL (0.39) | LPLLIPGF11EGFRCA1 | |
| SCHEMBL14509140 | 0.79 | ALDH1A1 (0.44) | LPLLIPGF11FFAR1HCAR1 | |
| SCHEMBL17592829 | 0.78 | LPL (0.49) | LPLLIPGF11FFAR1HCAR1 | |
| SCHEMBL7887164 | 0.78 | LPL (0.49) | LPLLIPGEGFRCA1CA2 | |
| SCHEMBL1494499 | 0.78 | TP53 (0.43) | LPLLIPGF11EGFRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |