Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032513 | 1.00 | ATR (0.40) | ATRBRD4GAAMAPTLMNA | |
| SCHEMBL27032154 | 0.93 | ATR (0.43) | ATRBRD4BCHECNR2CD274 | |
| SCHEMBL29925610 | 0.93 | ATR (0.43) | ATRBRD4BCHECNR2CD274 | |
| SCHEMBL27032444 | 0.81 | SIRT2 (0.44) | ATRGAAMAPTLMNAMAPK1 | |
| SCHEMBL29925612 | 0.81 | SIRT2 (0.44) | ATRGAAMAPTLMNAMAPK1 | |
| SCHEMBL29925930 | 0.72 | ATR (0.34) | ATRCNR2 | |
| SCHEMBL27032307 | 0.72 | ATR (0.34) | ATRCNR2 | |
| SCHEMBL24858387 | 0.71 | ATR (0.43) | ATRBRD4CNR2PTGS2 | |
| SCHEMBL24858378 | 0.71 | ATR (0.45) | ATRBRD4CNR2PTGS2MEN1 | |
| SCHEMBL29925841 | 0.70 | ATR (0.45) | ATRBRD4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |