Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032041 | 1.00 | ATR (0.45) | ATRBRD4CMKLR1CA12CA1 | |
| SCHEMBL27032273 | 0.91 | ATR (0.43) | ATRBRD4CA12CA1CA2 | |
| SCHEMBL29925873 | 0.91 | ATR (0.43) | ATRBRD4CA12CA1CA2 | |
| SCHEMBL27032631 | 0.84 | ATR (0.47) | ATRBRD4CA12CA1CA2 | |
| SCHEMBL24013151 | 0.81 | BRD4 (0.41) | BRD4CMKLR1 | |
| SCHEMBL30242656 | 0.78 | BRD4 (0.41) | ATRBRD4 | |
| SCHEMBL24013067 | 0.78 | BRD4 (0.41) | ATRBRD4 | |
| SCHEMBL24013078 | 0.78 | BRD4 (0.40) | BRD4 | |
| SCHEMBL30242573 | 0.78 | BRD4 (0.40) | BRD4 | |
| SCHEMBL24012967 | 0.78 | BRD4 (0.42) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |