Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 3/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27031936 | 1.00 | MEN1 (0.36) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL27032631 | 0.86 | ATR (0.47) | ATRCNR2 | |
| SCHEMBL29198557 | 0.84 | CNR1 (0.33) | ATR | |
| SCHEMBL27031973 | 0.83 | CYP4F2 (0.37) | MEN1KMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL29925776 | 0.83 | CYP4F2 (0.37) | MEN1KMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL27032476 | 0.83 | CYP4F2 (0.40) | MEN1KMT2AHRH3CYP4F2CYP4A11 | |
| SCHEMBL24012649 | 0.81 | CYP4F2 (0.40) | MEN1KMT2AHRH3CYP4F2CYP4A11 | |
| SCHEMBL27031960 | 0.80 | HTR3A (0.38) | CYP4F2CYP4A11ATRCNR2 | |
| SCHEMBL29925614 | 0.80 | HTR3A (0.38) | CYP4F2CYP4A11ATRCNR2 | |
| SCHEMBL27032051 | 0.78 | CYP4F2 (0.42) | CYP4F2CYP4A11ATRPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |