Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27031960 | 1.00 | HTR3A (0.38) | HTR3ABTKCYP4F2CYP4A11CMKLR1 | |
| SCHEMBL27032478 | 0.88 | CYP4F2 (0.39) | HTR3ABTKCYP4F2CYP4A11CMKLR1 | |
| SCHEMBL29925579 | 0.88 | CYP4F2 (0.39) | HTR3ABTKCYP4F2CYP4A11CMKLR1 | |
| SCHEMBL29925916 | 0.80 | MEN1 (0.36) | CYP4F2CYP4A11ATRCNR2 | |
| SCHEMBL27031936 | 0.80 | MEN1 (0.36) | CYP4F2CYP4A11ATRCNR2 | |
| SCHEMBL30971862 | 0.79 | KDR (0.37) | — | |
| SCHEMBL27032273 | 0.77 | ATR (0.43) | ATR | |
| SCHEMBL29925873 | 0.77 | ATR (0.43) | ATR | |
| SCHEMBL29925929 | 0.76 | CYP4F2 (0.39) | CYP4F2CYP4A11CMKLR1CNR2RXRA | |
| SCHEMBL27032089 | 0.76 | CYP4F2 (0.39) | CYP4F2CYP4A11CMKLR1CNR2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |