Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23810607 | 1.00 | PRMT5 (0.41) | PRMT5WDR77AAK1BACE1BACE2 | |
| SCHEMBL17206037 | 0.86 | HIF1A (0.41) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23321023 | 0.84 | BACE1 (0.31) | PRMT5WDR77AAK1BACE1BACE2 | |
| SCHEMBL6225537 | 0.83 | MAOB (0.44) | CA2CA9KDM4EALDH1A1HPGD | |
| SCHEMBL28339887 | 0.82 | PIM1 (0.51) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28507918 | 0.79 | AAK1 (0.43) | PRMT5WDR77AAK1BACE1BACE2 | |
| SCHEMBL24943919 | 0.78 | TAS1R3 (0.49) | LMNAALDH1A1 | |
| SCHEMBL19079911 | 0.78 | PRMT5 (0.55) | PRMT5WDR77AAK1BACE1BACE2 | |
| SCHEMBL2960924 | 0.77 | NPC1 (0.56) | ALDH1A1HPGDSMN1; SMN2FLT3 | |
| SCHEMBL3487931 | 0.76 | FLT3 (0.61) | F2PIM1CA2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087658-A | Sulfonamide or sulfenamide compounds having BRD 4-inducing proteolytic activity, and pharmaceutical use thereof | 田边三菱制药株式会社 | 2022-09-20 | — | — | CN | disclosed |