Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17206037 | 0.86 | HIF1A (0.41) | KDM4EALDH1A1MAPTMEN1HPGD | |
| SCHEMBL17206217 | 0.85 | MAOB (0.62) | MAOBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23810607 | 0.83 | PRMT5 (0.41) | KDM4EALDH1A1HPGDHSD17B10CA2 | |
| SCHEMBL29926382 | 0.83 | PRMT5 (0.41) | KDM4EALDH1A1HPGDHSD17B10CA2 | |
| SCHEMBL28339887 | 0.82 | PIM1 (0.51) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL17206222 | 0.79 | UCHL1 (0.39) | MAOBCA12CA2CA3CA4 | |
| SCHEMBL24943919 | 0.78 | TAS1R3 (0.49) | ALDH1A1MEN1USP2KMT2A | |
| SCHEMBL25777700 | 0.77 | CA12 (0.59) | MAOBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL1066982 | 0.77 | TAS1R3 (0.56) | MAOBKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL31604894 | 0.77 | PTGS2 (0.56) | KDM4EALDH1A1MAPTMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266892-B2 | Fused pyrazoles as FGFR inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266892-B2 | Fused pyrazoles as FGFR inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266892-B2 | Fused pyrazoles as FGFR inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-20140171405-A1 | Fused Pyrazoles as FGFR Inhibitors | INCYTE CORPORATION (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171405-A1 | Fused Pyrazoles as FGFR Inhibitors | INCYTE CORPORATION (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171405-A1 | Fused Pyrazoles as FGFR Inhibitors | INCYTE CORPORATION (US) | 2014-06-19 | — | — | US | disclosed |
| EP-1572693-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | PHARMACIA CORPORATION | 2004-10-21 | — | — | US | disclosed |
| WO-2004058762-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171405-A1 | Fused Pyrazoles as FGFR Inhibitors | FGFR1, FGFR3, FGFR2 | MAOB 3783/4885KDM4E 1034/4885ALDH1A1 555/4885 |
| US-20040209897-A1 | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds | MAPKAPK2, MAP3K2, MKNK2 | MAOB 1951/4885KDM4E 2767/4885ALDH1A1 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.