SCHEMBL29928359

SCHEMBL29928359

CNCc1cc(Oc2ccc(N3CCC(N)CC3)nc2)nc(-c2cc(C)cc(Cl)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ FURIN P09958 19/20 0.49
▸ SSTR2 P30874 1/20 0.36
▸ KCNH2 Q12809 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21551606 1.00 FURIN (0.49) FURINSSTR2KCNH2
SCHEMBL21564398 0.84 FURIN (0.48) FURIN
SCHEMBL26077370 0.82 FURIN (0.49) FURIN
SCHEMBL21550748 0.82 FURIN (0.39) FURINSSTR2KCNH2
SCHEMBL29928103 0.82 FURIN (0.39) FURINSSTR2KCNH2
SCHEMBL21551103 0.80 FURIN (0.58) FURIN
SCHEMBL29928234 0.77 FURIN (0.72) FURIN
SCHEMBL21550570 0.77 FURIN (0.72) FURIN
SCHEMBL30931829 0.77 FURIN (0.53) FURIN
SCHEMBL21551754 0.77 FURIN (0.53) FURIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112384509-B Furin inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2024-04-30 — — CN claimed
EP-4125897-A1 FURIN INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS BP Asset V, Inc. (US) 2023-02-08 — — EP claimed
CN-115666567-A Furin inhibitors for the treatment of coronavirus infection BP资产V股份有限公司 2023-01-31 — — CN claimed
EP-4058021-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES BP Asset V, Inc. (US) 2022-09-21 — — EP claimed
CN-112384509-B Furin inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2024-04-30 — — CN disclosed
US-20230149401-A1 FURIN INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS BP ASSET V, INC. (US) 2023-05-18 — — US disclosed
US-20230011571-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES BP ASSET V, INC. (US) 2023-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230011571-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES FURIN, LGMN, PLAU FURIN 1/4885SSTR2 4645/4885KCNH2 4115/4885
US-20230149401-A1 FURIN INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS FURIN, ACE, ACE2 FURIN 1/4885SSTR2 1641/4885KCNH2 2094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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