Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160677 | 0.71 | AXL (0.59) | HTR2CAXLMKNK1MKNK2KDR | |
| SCHEMBL15072216 | 0.71 | LMNA (0.57) | HTR2CAXLMKNK1MKNK2ADORA2A | |
| SCHEMBL15076957 | 0.65 | LMNA (0.41) | HTR2CAXLMKNK1MKNK2ADORA2A | |
| SCHEMBL31337089 | 0.65 | HTR2C (0.65) | HTR2CAXLMKNK1MKNK2PIK3CA | |
| SCHEMBL4193100 | 0.65 | HTR2C (0.65) | HTR2CAXLMKNK1MKNK2PIK3CA | |
| SCHEMBL28057522 | 0.65 | HTR2C (0.70) | HTR2CAXLMKNK1MKNK2PIK3CA | |
| SCHEMBL1601717 | 0.65 | HTR2C (0.70) | HTR2CAXLMKNK1MKNK2PIK3CA | |
| SCHEMBL659673 | 0.64 | AXL (1.00) | HTR2CAXLMKNK1MKNK2ADORA2A | |
| SCHEMBL14107782 | 0.64 | HTR2C (0.63) | HTR2CADORA2AKITPDE4APDE4B | |
| SCHEMBL1601613 | 0.64 | HTR2C (1.00) | HTR2CAXLMKNK1MKNK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | claimed |
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |