Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611763 | 1.00 | HPGD (0.41) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23623266 | 0.95 | HPGD (0.40) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23623298 | 0.91 | HPGD (0.40) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23623261 | 0.90 | HPGD (0.41) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23623300 | 0.85 | KMT2A (0.42) | HPGDSMN1; SMN2ALDH1A1CHEK1KDM4E | |
| SCHEMBL23623315 | 0.82 | ERCC1 (0.38) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23623630 | 0.81 | DRD2 (0.43) | ALDH1A1 | |
| SCHEMBL23623308 | 0.80 | KMT2A (0.41) | HPGDCHEK1KDM4ENPC1HDAC3 | |
| SCHEMBL23611743 | 0.79 | ERCC1 (0.37) | HPGDALDH1A1GRK6ERCC1FEN1 | |
| SCHEMBL29930728 | 0.79 | ERCC1 (0.37) | HPGDALDH1A1GRK6ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |