Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 4/20 | 0.37 |
| ▸ | FEN1 | P39748 | 4/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611743 | 1.00 | ERCC1 (0.37) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623421 | 0.95 | MYC (0.38) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623315 | 0.95 | ERCC1 (0.38) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623314 | 0.93 | ERCC1 (0.39) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623340 | 0.89 | ERCC1 (0.35) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623266 | 0.83 | HPGD (0.40) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23611763 | 0.79 | HPGD (0.41) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL29930610 | 0.79 | HPGD (0.41) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623261 | 0.78 | HPGD (0.41) | ERCC1FEN1ERCC4HPGDALDH1A1 | |
| SCHEMBL23623298 | 0.77 | HPGD (0.40) | ERCC1FEN1ERCC4HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |